Why Do We Have Cannabinoid Receptors?
An Overview: Endocannabinoid System
by the cannabis access resource & education center

Raphael Mechoulam: [Cannabis as a medicine] was never "seriously investigated" in Western medicine. There are very few clinical trials. It was not, and it is not "seriously used" in official Western medicine. (2014) . #endocannabinoidsstem #ECS #RaphaelMechoulam #cannabisasmedicine #medicialmarijuana #cannabismedicine #mmj #weed #marijuanamedicine educateoncannabis #cannabishistory #marijuana #cannabis #cannabinoidreceptors . The Endocannabinoid System: A History of Endocannabinoids and Cannabis http://www.marijuanatimes.org/the-endocannabinoid-system-a-history-of-endocannabinoids-and-cannabis/ . A random walk through a cannabis field https://www.researchgate.net/publication/21348900_A_random_walk_through_a_cannabis_field . Dr. Raphael Mechoulam: The Promise of Cannabis http://www.thedailybell.com/cannabis-marijuana/anthony-wile-dr-raphael-mechoulam-the-promise-of-cannabis/ . Graphic design with part of a photograph by Tzahy via Wikimedia Commons. https://commons.wikimedia.org/wiki/File%3AProfessor_Raphael_Mechoulam.jpg . . #BecauseWeCARE #learnonline #CARECenterTO #cannabiscommunity . .

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Scientists, although long realizing that cannabis affects humans (1800s), only recently began looking into how cannabis does that.

It was discovered (1990) that cannabinoid receptors were located in brain cells. Yet after showing that tetrahydrocannabinol (1964) fit into these CB1 receptors, scientists still didn't know why the brain had receptors for tetrahydrocannabinol (THC).

So, it was not until after the identification of the first endocannabinoid, anandamide (1992), that the existence of the endocannabinoid system (ECS) was revealed.

More recently (2000s), the endocannabinoid system is recognized as an important regulating system. The ECS is the pathway that allows cells within to communicate to different types of cells, and allows parts of a cell to communicate to other cell parts. Its function is to maintain homeostasis despite fluctuations in the internal and external environments.

The ECS consists of cannabinoid receptors, endogenous cannabinoids, and enzymes that either create or destroy endocannabinoids.



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11 Mind-blowing Facts about your Body's Endocannabinoid System
Have you ever wondered how and why cannabis can treat so many different illnesses? Gregory Frye says, "It's a great question and luckily there is a great answer based on scientific research."
List | learngreenflower.com | 2017
A Rudimentary Look at the Endocannabinoid System
Paul Nyishar, nutrition and herbal medicine consultant, presents a timeline of cannabis research and an explanation of how cannabis takes effect on a cellular level. [12 min.]
Video & Transcript | nyishar.com | 2016
Cannabinoid Receptor Antagonist
A cannabinoid receptor antagonist is a type of cannabinoidergic drug that binds to cannabinoid receptors (CBR) and prevents their activation by endocannabinoids. THCV is an antagonist to CB1 receptors.
Wiki | wikivisually.com | 2017
Cannabinoid Science by Dr David Allen
Steve Kubby, KUBBY TV, introduces Dr. David Allen who explains, in 2013, that ignorance of the endocannabinoid system is not bliss. [22 min.]
Video | KUBBY TV | 2013
Cannabinoids and Cannabis Chemistry
Good News with Nurse Heather and Canna Kenny, interview Dr. Robert Melamede, Ph.D. in Molecular Biology and Biochemistry, about his busy retirement, commercializing Phoenix Tears, what Dr. Bob has learned about cannabinoid science, how our endocannbinoid system is part of Human evolution, cannabinoid deficiency, and what happens to the world when we get high. [33 min.]
Audio | cannabisradio.com | 2016
Cannabis and the Endocannabinoid System
Dr. Bob Melamede, Ph.D. in Molecular Biology and Biochemistry, is interviewed on CannabisRadio and talks about what cancer eats and how cannabis combats it. Also discussed is why doctors are ignorant to cannabis and endocannabinoid system facts. [32:46 min.]
Audio | cannabisradio.com | 2017
Endocannabinoid Enhancer
An endocannabinoid enhancer (eCBE) is a type of cannabinoidergic drug that enhances the activity of the endocannabinoid system by increasing extracellular concentrations of endocannabinoids. Examples of different types of eCBEs include:
Wiki | wikivisually.com | 2018
Endocannabinoid System
Dr. Dustin Sulak, expert on medical cannabis, states the goal of the endocannabinoid system (ECS) is to maintain a stable internal environment despite fluctuations in external environment. In addition, the ECS can influence a person's relationship with the external environment with the administration of cannabinoids, especially THC.
Article | healer.com | 2015
Endocannabinoid System
Slideshow graphics and facts about the endocannabinoid system, cannabinoids, CB1 /CB2 receptors, effects, and medical applications.
InfoGraphic | leafscience.com | 2014
Endocannabinoid System
The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. The ECS is involved in a variety of physiological processes including:
Wiki | wikivisually.com | 2018
Endocannabinoid System Quiz
A wikipedia quiz with 10 multiple choice questions about the endocannabinoid system. Q. 1: "It is thought that hypothalamic neurons tonically produce endocannabinoids that work to tightly regulate ________. a) Starvation, b) Hunger, c ) Malnutrition, or d) Famine."
Quiz | wiki | 2017
How to Stimulate the Endocannabinoid System Without Cannabis
Leading clinician in the application of medical cannabis, Dr. Dustin Sulak explains that to help our bodies makes endocannabinoids, we need to eat endocannabinoid-enhancing foods containing essential fatty acids, chocolate, herbs, spices, and teas.
Article | leafly.com | 2018
Just Eat It! The Endocannabinoid System
Research indicates that non-cannabis plant and food sources provide nutrients, such as omegas, beta-caryophyllene, and flavonoids, that can help alleviate endocannabinoid deficiency.
Article | elevatenv.com | 2016
Medical Cannabis and the Endocannabinoid System
A quick look at the endocannabinoid system (ECS) and how it functions normally, and how the body responds to plant cannabinoids. Video developed by Fundación CANNA. [3 min.]
Video | Fundación CANNA | 2017
The Complex Interactions of THC, CB1, and the Endocannabinoids
Hui-Chen Lu and Ken Mackie review how synapses respond to the endocannabinoid system (ECS) and how the ECS is upset in schizophrenia.
Author Manuscript | ncbi.nlm.nih.gov | 2016
The Discovery of the Endocannabinoid System
Dr. David Allen, cannabinoid research scientist, reviews the important findings of the endocannabinoid system (ECS), which was discovered 30 years ago. [3:36 min.]
Video | Hemp Life Today | 2014
The Endocannabinoid System
A guided look at cannabinoids, cannabinoid receptors, endocannabinoids, and the endocannabinoid system.
Article | truthonpot.com | 2013
The Endocannabinoid System
How is it possible that one herb can affect every aspect of our bodies and minds? Dr. Dustin Sulak explains how and why cannabis works. [3 min.]
Video | healer.com | 2015
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
A review of public articles dealing with cannabinoid biology which demonstrates a steady growth of indications for the potential therapeutic use of cannabinoid-related medications targeting pain, obesity, and multiple sclerosis.
Review | pharmrev.aspetjournals.org | 2006
The Endocannabinoid System in Health and Disease:
Watch Dr. Ethan Russo give a talk on day-1 of the 2016 Medicinal Cannabis Symposium in Australia. [52:28 min.] - 15 minutes - - 29 minutes - - 41 minutes -
Video Talk | Medicinal Cannabis Symposium, Australia | 2016
The Reason our Bodies so Easily Process Cannabis
Due to the drug war and resulting shortage of cannabis research material, not a lot of cannabis-as-medicine research was conducted until the mid-nineties, when a prominent Israeli scientist, Dr. Ralph Mechoulam, discovered that our bodies not only have receptor sites cued just for cannabinoids, but that our bodies actually produce them internally. Author and cannabis consultant Rick Pfrommer predicts it will be another 20 years before cannabis-based medicines will have a prominent place in the worldwide pharmacopeia again.
Article | reset.me | 2015
Things to Know about the Endocannabinoid System
Five facts:
Article | herb.co | 2015
Visualization of the Endocannabinoid Signaling System
An animated look at the ascending and descending pain signal pathways in the presence of either endogenous or exogenous cannabinoids. Leanne Chan's Master's Research Project, produced in collaboration with the University of Toronto and funded by the Quebec Pain Research Network. [5:08 min.]
Video | Quebec Pain Research Network | 2011